Nonreceptor interactions in the pharmacology of blood platelets.
نویسندگان
چکیده
On the basis of values corresponding to concentrations exhibiting 50% inhibition of platelet aggregation induced with different stimuli and 50% inhibition of arachidonic acid liberation and thromboxane generation, we compared the antiplatelet effect of two cationic amphiphilic drugs--chloroquine and dithiaden. Compared to chloroquine, dithiaden was much more effective in inhibiting platelet aggregation, A-23187 induced arachidonic acid liberation and thromboxane generation. Chloroquine, on the other hand, was more effective in the inhibition of thrombin-induced arachidonic acid liberation.
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ورودعنوان ژورنال:
- General physiology and biophysics
دوره 18 Spec No شماره
صفحات -
تاریخ انتشار 1999